Everything about ceesdekker.net
Everything about ceesdekker.net
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
1996, very first mesoscopic demand density waves devices; and very first electrical measurements on only one metal nanocluster amongst nanoelectrodes
[Laughs] ‘It had been absolutely a terrific chance! At time, I was nicely aware that it could go wrong Which I could turn into a lot less effective, but I just dismissed that. Curiosity has usually been my strongest driving drive. And fortunately all of it worked out.’
Our work was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors created from solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. In only a few months, we ended up in a position to evaluate transport by a person one-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Our analysis ranges through the biophysics of DNA to synthetic cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
A lot of linked developments adopted, wherever our team founded distinctive transistor variants which include single-electron transistors at room temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into little proof-of-basic principle Digital circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is shown in gray, the rim from the pore is highlighted in purple, along with a 3D rendering of your motion with the DNA rod is displayed.
The rotors harness Electrical power from the nanoscale water and ion move that is definitely produced by a static chemical or electrochemical potential gradient during the nanopore, that happen to be set up via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and function autonomously in physiological disorders, suggesting solutions to constructing Electrical power-transducing motors at nanoscale interfaces.
There was just one trouble though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been in fact not these terrific conductors, which was alternatively disappointing. We thus broadened our see to try to locate much more promising molecules.
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2001, discovery of solitary-electron transistors at place temperature dependant on nanotubes; realization of to start with logic circuits with carbon nanotube devices; and discovery of the molecular structure of DNA restore enzymes with AFM
Developments in nanotechnology while in the nineteen nineties designed setting up Digital equipment from one molecules a risk. Cees Dekker recounts how his workforce created a room-temperature transistor based on a single carbon nanotube.
2004, discovery of new physics in translocation of DNA by nanopores; 1st experimental research of ions conduction in nanofluidic channels; to start with electrochemistry with particular person solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization of your mechanical Homes of double-stranded RNA; and initial one-molecule research of DNA translocation by a restriction-modification enzyme.